Antibodies to human T cell leukemia virus are absent in patients with systemic lupus erythematosus.

Abstract

It has been anticipated that type C oncornaviruses, which participate in the pathogenesis of murine systemic lupus erythematosus (SLE), would be found to have a role in the development of SLE in humans. In studies of tissues from SLE patients, type C-related proteins have been identified. Using information obtained on the recent isolation of the human T cell leukemia virus (HTLV), together with that from studies of murine SLE, we attempted to clarify the role of antibodies to HTLV in the pathogenesis of human SLE. Using a solid-phase enzyme-linked immunosorbent assay and sodium dodecyl sulfate-polyacrylamide gel electrophoretic techniques, we were unable to find evidence of the participation of antibodies to HTLV proteins in the development of human SLE.

• Authors: T Koike, M Kagami, K Takabayashi, N Maruyama, H Tomioka, S Yoshida
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 28 Issue 5 Pg. 481-4 (May 1985) ISSN: 0004-3591 [Print] United States
• PMID: 2988571 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Sodium Dodecyl Sulfate

Topics

• Antibodies, Viral (immunology)
• Deltaretrovirus (immunology)
• Electrophoresis, Polyacrylamide Gel
• Enzyme-Linked Immunosorbent Assay
• Humans
• Lupus Erythematosus, Systemic (immunology)
• Sodium Dodecyl Sulfate