99mTc-Phy portal perfusion index imaging helps predict the severity of hepatitis B virus cirrhosis: a preliminary study.

Abstract

OBJECTIVE:

The aim was to perform exploratory research on the application of technetium phytate (Tc-Phy) portal perfusion index (PPI) imaging in predicting the complications of hepatitis B cirrhosis and their severity.

PATIENTS AND METHODS:

A total of 65 hepatitis B cirrhosis patients were stratified, respectively, into three groups from classes A to C according to Child-Pugh scores and five groups from stages 1 to 5 according to the five-stage prognostic system. PPIs were compared and analyzed, respectively, among the three and five groups. The correlations between PPIs and major biochemical indices of liver function were also analyzed. One-way analysis of variance was used to compare the PPIs among the various groups and a nonparametric Spearman test was used to analyze the correlations between PPIs and various biochemical indices.

RESULTS:

PPIs of the five groups decreased gradually from stage 1 to stage 5 (73.03±8.49, 52.96±16.22, 46.24±15.25, 29.99±17.36, and 11.50±6.37, respectively); with the exception of the difference between stages 2 and 3 (P=0.252), the differences between the remaining groups were statistically significant (P<0.05). The PPI showed positive correlations with serum total protein, serum albumin, and albumin/globulin results (r=0.292, 0.559, 0.520, respectively; P<0.05), and negative correlations with serum globulin (r=-0.366, P<0.05).

CONCLUSION:

Technetium phytate PPI could be a promising noninvasive and effective method for predicting the complications of hepatitis B cirrhosis and their severity; a lower PPI value indicates a higher severity of complications for hepatitis B cirrhosis patients. PPI can provide very meaningful reference data for clinical practice.

• Authors: Ning-Hu Liu, Meng-Jie Dong, Hao Liu, Xi-Li Lu, Dan Tian, Jun Zhang, Jun Yang, Jun-Hui Sun, Li-Hua Wu, Jian-Li Bi, Bo Zhang
• Journal: Nuclear medicine communications (Nucl Med Commun) Vol. 39 Issue 9 Pg. 818-824 (09 2018) ISSN: 1473-5628 [Electronic] England
• PMID: 29877993 (Publication Type: Journal Article)

Chemical References

• Organotechnetium Compounds
• technetium phytate
• Phytic Acid

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Female
• Hepatitis B virus (physiology)
• Humans
• Liver Cirrhosis (diagnostic imaging, metabolism, physiopathology, virology)
• Male
• Middle Aged
• Organotechnetium Compounds
• Perfusion Imaging
• Phytic Acid
• Portal Vein (diagnostic imaging)
• Prognosis
• Young Adult