Abstract | BACKGROUND/AIM: PET with 6-[18F]fluor- l-3,4-dihydroxyphenylalanine (18F-FDOPA) has been shown to be a useful imaging tool with a high sensitivity for the visualization of neuroendocrine tumors (NETs). 18F-FDOPA uptake in tumors other than NETs has been suggested previously, but data on this phenomenon are limited. We therefore studied the non-physiological, false-positive uptake of 18F-FDOPA in a large population of patients with a NET or with a high clinical suspicion of harboring a NET. PATIENTS AND METHODS: Retrospective single-center study among adult patients in whom 18F-FDOPA PET scintigraphy was performed between January 2004 and December 2014. The original scan report was compared with the original pathology report corresponding with the 18F-FDOPA PET-positive lesion. In case this was inconsistent with the diagnosis of a NET, both the scan and the pathology slides were reassessed. Specimens of these non-NET tissues were immunohistochemically stained for AADC. RESULTS: CONCLUSIONS: Pathological uptake of 18F-FDOPA does not always indicate the presence of a NET. The possibility of 18F-FDOPA uptake by tumor types other than NETs, although rare, should be considered.
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Authors | Annika M A Berends, Michiel N Kerstens, Janne W Bolt, Thera P Links, Esther Korpershoek, Ronald R de Krijger, Annemiek M E Walenkamp, Walter Noordzij, Boudewijn van Etten, Gursah Kats-Ugurlu, Adrienne H Brouwers, Anouk N A van der Horst-Schrivers |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 179
Issue 2
Pg. 125-133
(Aug 2018)
ISSN: 1479-683X [Electronic] England |
PMID | 29875288
(Publication Type: Journal Article)
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Copyright | © 2018 European Society of Endocrinology. |
Chemical References |
- fluorodopa F 18
- Dihydroxyphenylalanine
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Topics |
- Adrenal Gland Neoplasms
(diagnostic imaging, metabolism, pathology)
- Adult
- Aged
- Dihydroxyphenylalanine
(administration & dosage, analogs & derivatives, metabolism, pharmacokinetics)
- False Positive Reactions
- Female
- Humans
- Immunohistochemistry
- Intestinal Neoplasms
(diagnostic imaging, metabolism, pathology)
- Male
- Middle Aged
- Neuroendocrine Tumors
(diagnostic imaging, metabolism, pathology)
- Pancreatic Neoplasms
(diagnostic imaging, metabolism, pathology)
- Paraganglioma
(diagnostic imaging, metabolism, pathology)
- Pheochromocytoma
(diagnostic imaging, metabolism, pathology)
- Positron-Emission Tomography
- Radionuclide Imaging
- Retrospective Studies
- Stomach Neoplasms
(diagnostic imaging, metabolism, pathology)
- Tissue Distribution
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