Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction.

Abstract

BACKGROUND:

The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1α and IL-1β are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine whether levels of soluble regulators of IL-1 signalling are changed during ST-elevation MI (STEMI) and their associations with parameters of cardiac injury and ventricular remodelling.

METHODS:

Plasma levels of IL-1Ra, sIL-1R1, sIL-1R2 and sIL-1R accessory protein (sIL-1RAcP) were measured by immunoassays in repeated samples from patients with STEMI (n = 255) and compared to healthy controls (n = 65).

RESULTS:

IL-1Ra, sIL-1R1 and sIL-1R2 levels were all significantly elevated after STEMI, while levels of sIL-1RAcP were lower compared to controls. sIL-1R2 levels (at different time points) correlated positively with C-reactive protein, myocardial infarct size and change in indexed left ventricular end-diastolic and end-systolic volume (LVEDVi and LVESVi) measured by cardiac MR acutely and after 4 months, and negatively with LV ejection fraction. Patients with >median levels of sIL-1R2 in the acute phase were more likely to have increased change in LVEDVi and LVESVi. Importantly, sIL-1R2 remained significantly associated with change in LVEDVi and LVESVi also after adjustment for clinical covariates.

CONCLUSION:

Levels of sIL-1R2 are independently associated with parameters of LV adverse remodelling following STEMI.

• Authors: Hilde L Orrem, Christian Shetelig, Thor Ueland, Shanmuganathan Limalanathan, Per H Nilsson, Trygve Husebye, Pål Aukrust, Ingebjørg Seljeflot, Pavel Hoffmann, Jan Eritsland, Tom E Mollnes, Geir Øystein Andersen, Arne Yndestad
• Journal: International journal of cardiology (Int J Cardiol) Vol. 268 Pg. 187-192 (Oct 01 2018) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 29853279 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• IL1R2 protein, human
• Receptors, Interleukin-1 Type II

Topics

• Aged
• Biomarkers (blood)
• Female
• Humans
• Male
• Middle Aged
• Percutaneous Coronary Intervention (trends)
• Receptors, Interleukin-1 Type II (blood)
• ST Elevation Myocardial Infarction (blood, diagnostic imaging, surgery)
• Stroke Volume (physiology)
• Ventricular Remodeling (physiology)