Intracameral moxifloxacin after cataract surgery: a prospective study.

Abstract

OBJECTIVE:

To study the safety parameters associated with intracameral moxifloxacin application five weeks after cataract surgery.

METHODS:

The study was a prospective case series set in a private hospital in Recife, Pernambuco, Brazil. A consecutive sample of 1,016 cataract surgeries was evaluated. The inclusion criteria were patients with indications for cataract surgery, a minimum of 55 years of age, and no history of allergy to quinolones. Patients were prepared for surgery using a 5% povidone solution diluted as a topical antiseptic agent. The operative technique was phacoemulsification with intraocular lens implantation. A 0.3-mL syringe was partially filled with moxifloxacin and 150 µg/0.03 mL of moxifloxacin was administered through the surgical incision at the end of the surgery. Postoperatively, patients were prescribed: (1) 0.5% moxifloxacin eyedrops 5 times daily for 1 week, and (2) 1% prednisolone acetate eyedrops 5 times daily for 1 week, followed by 4 times daily for 1 week and, subsequently, 2 times daily for 3 weeks. The outcomes were incidence of acute endophthalmitis, mean changes from baseline to 5 postoperative weeks in corneal endothelial cell density, corrected distance visual acuity and intraocular pressure.

RESULTS:

The mean age was 67 ± 5 years, and 56.2% of the patients were female. There were no cases of endophthalmitis. The mean preoperative corrected distance visual acuity was 58 letters ± 10 (SD), and the mean postoperative corrected distance visual acuity was 80 letters ± 4 (SD). The mean change in corneal endothelial cell density was 249 cells/mm (-10.3%). There was almost no difference in intraocular pressure. No study-related adverse events were observed.

CONCLUSION:

The results suggest moxifloxacin is a safe option for intracameral use after cataract surgery.

• Authors: Nelise de Paiva Lucena, Indira Maria de Sousa Pereira, Maria Isabel Lynch Gaete, Kaline Sandrelli Alves Ferreira, Mathias Violante Mélega, Rodrigo Pessoa Cavalcanti Lira
• Journal: Arquivos brasileiros de oftalmologia (Arq Bras Oftalmol) Vol. 81 Issue 2 Pg. 92-94 (Apr 2018) ISSN: 1678-2925 [Electronic] Brazil
• PMID: 29846429 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Fluoroquinolones
• Moxifloxacin

Topics

• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (administration & dosage)
• Antibiotic Prophylaxis (methods)
• Endophthalmitis (etiology, physiopathology, prevention & control)
• Female
• Fluoroquinolones (administration & dosage)
• Humans
• Injections, Intraocular (methods)
• Intraocular Pressure (physiology)
• Lens Implantation, Intraocular (adverse effects)
• Male
• Middle Aged
• Moxifloxacin
• Phacoemulsification (adverse effects)
• Postoperative Complications (prevention & control)
• Prospective Studies
• Reproducibility of Results
• Statistics, Nonparametric
• Time Factors
• Treatment Outcome
• Visual Acuity (physiology)