Aerosol Delivery Devices for Obstructive Lung Diseases.

Abstract

Drug delivery by inhalation is the principal strategy to treat obstructive lung diseases, which affect about 15% of the population in the United States. Aerosol delivery devices have evolved over more than 60 years from the basic pressurized metered-dose inhaler and nebulizer to numerous types of inhalers and devices, including valved holder chambers, dry powder inhalers, soft mist inhalers, as well as smart inhalers and nebulizers. Although these devices improve a patient's ability to self-administer medication, many problems with optimal delivery still exist. Appropriate selection and repeated patient education can help lessen the problems with these devices. Aerosol science is evolving, with methods of measurement that include radio-scintigraphy and magnetic resonance imaging, to provide a better understanding of aerosol delivery and effects. Understanding the science and clinical application of aerosol drug delivery can substantially aid clinicians in optimizing these therapies for their patients.

• Authors: Roy A Pleasants, Dean R Hess
• Journal: Respiratory care (Respir Care) Vol. 63 Issue 6 Pg. 708-733 (Jun 2018) ISSN: 1943-3654 [Electronic] United States
• PMID: 29794206 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2018 by Daedalus Enterprises.

Chemical References

• Aerosols
• Bronchodilator Agents

Topics

• Administration, Inhalation
• Aerosols (administration & dosage, adverse effects)
• Asthma (drug therapy)
• Bronchodilator Agents (administration & dosage)
• Equipment Design
• Humans
• Nebulizers and Vaporizers
• Pulmonary Disease, Chronic Obstructive (drug therapy)