Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania.

Abstract

BACKGROUND:

This study aimed to assess heritability of myopia in Lithuania and evaluate both genes GJD2 (Gap Junction Protein, Delta 2) and RASGRF1 (RAS protein-specific guanine nucleotide-releasing factor 1) relation with myopia.

METHODS:

In this study Lithuanian twin population aged between 18 and 40 (n = 460) were examined. Single-nucleotide polymorphisms of the RASGRF1 (rs8027411) and GJD2 (rs634990) genes were assessed by real-time polymerase chain reaction method.

RESULTS:

Intrapair correlations for spherical equivalent in all twin pairs were significantly higher in MZ twin pairs r = 0.539 (p < 0.001, 95% CI 0.353-0.684) than in DZ twin pairs r = 0.203 (p < 0.01, 95% CI 0.0633-0.442) in myopia group. Correlations for spherical equivalent in emmetropia group were not significant in MZ twin pairs r = 0.091 (p > 0.05, 95% CI -0.215-0.381) and in DZ twin pairs r = - 0.220 (p > 0.05, 95% CI -0.587-0.222). The odds ratio (95% CI) were 2.7 (1.018-7.460) for combinations of genotypes of rs634990 CC and rs8027411 GT (p = 0.046).

CONCLUSIONS:

Our studies have shown that the heritability of myopia makes 67.2% in Lithuania. Persons with combinations of genotypes rs634990 CC and rs8027411 GT have 2.7 times higher odds to have myopia.

• Authors: Edita Kunceviciene, Margarita Sriubiene, Rasa Liutkeviciene, Ilona T Miceikiene, Alina Smalinskiene
• Journal: BMC ophthalmology (BMC Ophthalmol) Vol. 18 Issue 1 Pg. 124 (May 24 2018) ISSN: 1471-2415 [Electronic] England
• PMID: 29793445 (Publication Type: Journal Article)

Chemical References

• Connexins
• RASGRF1 protein, human
• ras-GRF1

Topics

• Adolescent
• Adult
• Connexins (genetics)
• Diseases in Twins
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Lithuania
• Male
• Myopia (genetics)
• Odds Ratio
• Polymorphism, Single Nucleotide
• Real-Time Polymerase Chain Reaction
• Refractive Errors (genetics)
• Young Adult
• ras-GRF1 (genetics)