The efficacy and safety of other cryotherapy compounds for the treatment of genital warts: a randomized controlled trial.

Abstract

BACKGROUND:

Cryotherapy using Wartner compound that contains a mixture of dimethyl ether (75%) and propane (25%) has been recently reported as an effective treatment for warts. The present study aimed to evaluate the safety and efficacy of Wartner in male patients with genital warts.

METHODS:

A Phase II parallel-randomized clinical trial was performed on 16 Iranian men affected by genital warts who were referred to a dermatology clinic at Tehran University of Medical Sciences. Two genital warts of each patient were selected and randomly assigned to receive either Wartner (intervention) or liquid nitrogen (control).

RESULTS:

Two weeks after the treatment, the sizes of the lesions in control and intervention groups decreased by 17.87 ± 2.14 mm2 and 15.81 ± 1.80 mm2, respectively (p = .299). Fourteen days after a single session of treatment, 81% of lesions in the control group and 50% in the Wartner group were completely eradicated, however, the difference was not statistically significant (p = .063).

CONCLUSIONS:

The Wartner compound is as effective as the conventional cryotherapy method for treating genital warts. It is particularly valuable when there are contraindications or no access to common treatment options.

• Authors: A Firooz, H Hosseini, L Izadi Firouzabadi, M Nassiri Kashani, S A Nasrollahi
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 30 Issue 2 Pg. 176-178 (Mar 2019) ISSN: 1471-1753 [Electronic] England
• PMID: 29790804 (Publication Type: Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial)

Topics

• Adult
• Condylomata Acuminata (therapy)
• Cryotherapy (methods)
• Genital Diseases, Male (therapy)
• Humans
• Male
• Middle Aged
• Warts (therapy)