An in vivo biocompatibility study of surgical meshes made from bacterial cellulose modified with chitosan.

Abstract	Bacterial cellulose modified with chitosan (MBC) is an innovative biomaterial used in regenerative medicine which may potentially improve treatment outcomes mesh for hernia repair surgery by facilitating better absorption in native tissue with less risk of mesh-related infections. The aim of the present study was to evaluate the biocompatibility of mesh based on MBC, and determine whether immunological reactions occur due to hypersensitivity to the implants. Forty five Imp:WIST rats were randomly assigned to be implanted with one of three mesh types: simple polypropylene mesh (n = 15), mesh modified by bacterial cellulose only (n = 15) and MBC mesh (n = 15) and evaluated after one and three months following intramuscular implantation. For MBC mesh, basic toxicological studies, i.e. Acute Dermal Irritation, Intradermal Reactivity and Acute Sensitization (GPMT), were also carried out on 9 Imp:BN albino rabbits and 15 Imp:D-H guinea pigs. The lowest immune response and the highest degree of fibroplasia were observed for MBC mesh both after one and three months after implantation. Toxicological studies classified the tested MBC mesh as a barely perceptible irritant with no signs of sensitization or allergic reactions observed during the studies. The findings indicate that MBC mesh does not irritate, does not sensitize and does not cause hypersensitivity in the implant site, and therefore presents a low risk of provoking such reactions in humans.
Authors	Joanna Piasecka-Zelga, Piotr Zelga, Joanna Szulc, Justyna Wietecha, Danuta Ciechańska
Journal	International journal of biological macromolecules (Int J Biol Macromol) Vol. 116 Pg. 1119-1127 (Sep 2018) ISSN: 1879-0003 [Electronic] Netherlands
PMID	29782983 (Publication Type: Journal Article)
Copyright	Copyright © 2018 Elsevier B.V. All rights reserved.
Chemical References	Cellulose Chitosan
Topics	Animals Cellulose (chemistry, pharmacology) Chitosan (chemistry, pharmacology) Gluconacetobacter xylinus (chemistry) Guinea Pigs Materials Testing Rabbits Rats Rats, Wistar Surgical Mesh

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