HIV Dementia with a Decreased Cardiac 123I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies.

Abstract

Cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a promising biomarker for dementia with Lewy bodies (DLB). However, we experienced a patient with cognitive decline, parkinsonism, and a decreased MIBG uptake who turned out to have HIV dementia. Normal dopamine transporter single-photon emission computed tomography reduced the possibility of comorbid Lewy body pathology causing the patient' s parkinsonism. The decreased MIBG uptake was most likely due to postganglionic sympathetic nerve denervation, which can also be caused by HIV. This case further emphasizes the importance of excluding other causes of autonomic neuropathy, including HIV infection, before interpreting MIBG scans.

• Authors: Masanori Kurihara, Takuya Sasaki, Hiroyuki Ishiura, Shoji Tsuji
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 57 Issue 20 Pg. 3007-3010 (Oct 15 2018) ISSN: 1349-7235 [Electronic] Japan
• PMID: 29780124 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Retroviral Agents
• Biomarkers
• Radiopharmaceuticals
• 3-Iodobenzylguanidine

Topics

• 3-Iodobenzylguanidine (blood)
• AIDS Dementia Complex (diagnosis, drug therapy, etiology)
• Anti-Retroviral Agents (therapeutic use)
• Biomarkers (blood)
• Cognitive Dysfunction (diagnosis, drug therapy)
• Fatal Outcome
• HIV Infections (complications, mortality)
• Humans
• Lewy Bodies
• Lewy Body Disease (drug therapy, etiology)
• Male
• Middle Aged
• Radiopharmaceuticals (blood)
• Sympathetic Nervous System (diagnostic imaging)
• Tomography, Emission-Computed, Single-Photon (methods)