Abstract | BACKGROUND: Caudal dorsomedial hindbrain detection of hypoglycemia-associated lactoprivation regulates glucose counter-regulation in male rats. In females, estradiol (E) determines hypothalamic neuroanatomical and molecular foci of hindbrain energy sensor activation. This study investigated the hypothesis that E signal strength governs metabolic neuropeptide and counter-regulatory hormone responses to hindbrain lactoprivic stimuli in hypoglycemic female rats. METHODS: Ovariectomized animals were implanted with E-filled silastic capsules [30 (E-30) or 300 μg (E-300)/mL] to replicate plasma concentrations at estrous cycle nadir versus peak levels. E-30 and E-300 rats were injected with insulin or vehicle following initiation of continuous caudal fourth ventricular L- lactate infusion. RESULTS: CONCLUSIONS: Distinct physiological patterns of E secretion characteristic of the female rat estrous cycle elicit differential corticosterone outflow during hypoglycemia, and establish both common and different hypothalamic metabolic neurotransmitter targets of hindbrain lactate deficit signaling. Outcomes emphasize a need for insight on systems-level organization, interaction, and involvement of E signal strength-sensitive neuropeptides in counter-regulatory functions.
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Authors | Santosh K Mandal, Prem K Shrestha, Fahaad S H Alenazi, Manita Shakya, Hussain N Alhamami, Karen P Briski |
Journal | Neuropeptides
(Neuropeptides)
Vol. 70
Pg. 37-46
(Aug 2018)
ISSN: 1532-2785 [Electronic] Netherlands |
PMID | 29779845
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
- Hypoglycemic Agents
- Insulin
- Neuropeptides
- Estradiol
- AMP-Activated Protein Kinases
- Norepinephrine
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Topics |
- AMP-Activated Protein Kinases
(metabolism)
- Animals
- Estradiol
(metabolism, pharmacology)
- Female
- Hypoglycemia
(metabolism)
- Hypoglycemic Agents
(pharmacology)
- Hypothalamus
(drug effects, metabolism)
- Insulin
(pharmacology)
- Neuropeptides
(metabolism)
- Norepinephrine
(metabolism)
- Rats, Sprague-Dawley
- Rhombencephalon
(drug effects, metabolism)
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