Application of Cu-64 NODAGA-PSMA PET in Prostate Cancer.

Abstract

INTRODUCTION:

The high diagnostic potential of 64Cu-PSMA PET-CT imaging was clinically investigated in prostate cancer patients with recurrent disease and in the primary staging of selected patients with advanced local disease. The aim of our study is to assess the uptake behavior in the clinical setting of 64Copper Prostate-Specific Membrane Antigen (64Cu PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) in prostate cancer.

METHODS:

A retrospective study was performed in 23 patients with intermediate, high risk and progressive disease at primary staging of prostate cancer. All patients underwent 64Cu-PSMA PET. Overall, 250 MBq (4 MBq per kg bodyweight, range 230-290 MBq) of 64Cu-NODAGA PSMA was intravenously applied. PET images were performed 30 min (pelvis and abdomen) and 1-2 h post-injection (skull base to mid-thigh). Maximum standardized uptake values (SUVmax) were measured in the organs with high physiological uptake such as liver and kidney, and, additionally, background activity was measured in the gluteal area and in suspected tumor lesions using a HERMES workstation.

RESULTS:

PSMA uptake was detected in prostate bed in nine patients, in six patients in distant metastases (bone, lung and liver) and in nine patients in lymph nodes. Of 23 patients, 5 (20.8%) did not show any focal pathological uptake in the whole body. The number of sites (prostate bed, lymph nodes, distant metastases) with positive PSMA uptake was significantly associated with PSA values before imaging (P = 0.0032). The 64Cu PSMA uptake increased significantly from 30 min to 1-3 h post-injection (Wilcoxon signed rank test, P = 0.002).

CONCLUSIONS:

64Cu NODAGA-PSMA PET is a promising imaging tool in the detection of residual disease in patients with recurrent or primary progressive prostate cancer. Furthermore, the increased tracer uptake over time indicates in vivo stability of the diagnostic radiopharmaceutical.

• Authors: Sabina Sevcenco, Hans Christoph Klingler, Klaus Eredics, Alexander Friedl, Jenifer Schneeweiss, Peter Knoll, Thomas Kunit, Lukas Lusuardi, Siroos Mirzaei
• Journal: Advances in therapy (Adv Ther) Vol. 35 Issue 6 Pg. 779-784 (06 2018) ISSN: 1865-8652 [Electronic] United States
• PMID: 29777523 (Publication Type: Journal Article)

Chemical References

• Acetates
• Antigens, Surface
• Copper Radioisotopes
• Copper-64
• Heterocyclic Compounds, 1-Ring
• Radiopharmaceuticals

Topics

• Acetates (therapeutic use)
• Aged
• Aged, 80 and over
• Antigens, Surface (therapeutic use)
• Copper Radioisotopes (therapeutic use)
• Heterocyclic Compounds, 1-Ring (therapeutic use)
• Humans
• Male
• Middle Aged
• Prostatic Neoplasms (drug therapy)
• Radiopharmaceuticals (therapeutic use)
• Retrospective Studies