[Analysis of prognostic factors for survival in 
elderly patients with glioma].

Abstract

OBJECTIVE:

To analyze the prognostic factors for survival in elderly patients with glioma.
 Methods: We performed a retrospective analysis of prognostic factors for elderly patients with glioma, who were treated by the same attending doctor during June 2014 and June 2016, to investigate the correlations of the age, dimension of pathology, histological grade, extent of resection, adjuvant therapy, preoperative Karnofsky Performance Scale (KPS) score, postoperative KPS score, molecular markers [isocitrate dehydrogenase-1 (IDH-1), O6-methylguanine DNA-transferase (MGMT), epidermal growth factor receptor (EGFR), Ki-67] with the prognosis.
 Results: A total of 45 patients were included in the study. The median overall survival (OS) was 11 months. The median progression-free survival (PFS) was 6 months. Univariate analysis revealed that the age, gender, dimension of pathology, histological grade and preoperative KPS score had no significant correlation with survival (P>0.05). The gross total resection, higher postoperative KPS score, adjuvant therapy, lower Ki-67 index were significantly correlated with survival. The expressions of MGMT and EGFR were significant factors for survival. High postoperative KPS score (P=0.019), adjuvant therapy (P=0.024), and the expression of MGMT (P=0.026) were independent predictors for increased median OS in a multivariate regression model.
 Conclusion: The extent of resection, adjuvant therapy, postoperative KPS score and molecular markers are the influential factors for survival. Larger prospective studies are needed to confirm these findings.

• Authors: Jinghui Liu, Miao Lou, Peigang Ji, Chen Li, Fuqiang Feng, Baofu Li, Meng Xu, Guodong Gao, Yan Qu, Liang Wang
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 43 Issue 4 Pg. 403-409 (Apr 28 2018) ISSN: 1672-7347 [Print] China
• PMID: 29774877 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Ki-67 Antigen
• Tumor Suppressor Proteins
• Isocitrate Dehydrogenase
• DNA Modification Methylases
• MGMT protein, human
• EGFR protein, human
• ErbB Receptors
• DNA Repair Enzymes

Topics

• Aged
• Biomarkers, Tumor (analysis)
• Brain Neoplasms (chemistry, mortality, therapy)
• DNA Modification Methylases (analysis)
• DNA Repair Enzymes (analysis)
• Disease-Free Survival
• ErbB Receptors (analysis)
• Glioma (chemistry, mortality, therapy)
• Humans
• Isocitrate Dehydrogenase (analysis)
• Karnofsky Performance Status
• Ki-67 Antigen (analysis)
• Prognosis
• Retrospective Studies
• Survival Analysis
• Tumor Suppressor Proteins (analysis)