A comparative study of EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine on Aβ42 induced cognitive deficiency in a rat model of Alzheimer's disease.

Abstract

Ethanolamine plasmalogen (pPE), a major phospholipid in neuronal membranes, is specifically reduced in postmortem brains from patients with Alzheimer's disease (AD). The purpose of the present study was to compare the effects of EPA-enriched ethanolamine plasmalogen (EPA-pPE) and EPA-enriched phosphatidylethanolamine (EPA-PE) on cognitive deficiency and illustrate the possible underlying mechanisms. SD rats were divided into four groups including the sham group injected with 0.9% saline and three amyloid-β (Aβ) infusion groups, Aβ42 group, EPA-pPE group and EPA-PE group. EPA-pPE and EPA-PE were administered by gavage (150 mg kg-1 day-1), respectively, once a day for 26 days. Administration of EPA-pPE exerted better effects than EPA-PE in improving Aβ-induced cognitive deficiency in a rat model of Alzheimer's disease. Further mechanical research indicated that EPA-pPE was superior to EPA-PE in regulating oxidative stress via increasing SOD activity and decreasing MDA level, as well as reducing GSK-3β and tau phosphorylation. Moreover, EPA-PE was more effective than EPA-pPE at inhibiting the protein expressions of Bax and caspase 9. The results of neuro-inflammation and inflammasome activation showed that EPA-pPE exerted more significant effects than EPA-PE in inhibiting the expressions of TNF-α and IL-1β, and decreasing NLRP3, pro-caspase 1 and caspase 1 levels. EPA-pPE alleviated Aβ-induced neurotoxicity by inhibiting oxidative stress, neuronal injury, apoptosis and neuro-inflammation, which might depend on the vinyl ether linkage at the sn-1 position.

• Authors: Hongxia Che , Qian Li , Tiantian Zhang , Lin Ding , Lingyu Zhang , Haohao Shi , Teruyoshi Yanagita , Changhu Xue , Yaoguang Chang , Yuming Wang
• Journal: Food & function (Food Funct) Vol. 9 Issue 5 Pg. 3008-3017 (May 23 2018) ISSN: 2042-650X [Electronic] England
• PMID: 29774334 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Amyloid beta-Peptides
• Interleukin-1beta
• Phosphatidylethanolamines
• Plasmalogens
• phosphatidal ethanolamines
• phosphatidylethanolamine
• Eicosapentaenoic Acid
• Glycogen Synthase Kinase 3 beta

Topics

• Alzheimer Disease (drug therapy, genetics, metabolism, psychology)
• Amyloid beta-Peptides (genetics, metabolism, toxicity)
• Animals
• Apoptosis (drug effects)
• Cognition (drug effects)
• Eicosapentaenoic Acid (administration & dosage)
• Glycogen Synthase Kinase 3 beta (genetics, metabolism)
• Humans
• Interleukin-1beta (genetics, metabolism)
• Male
• Oxidative Stress (drug effects)
• Phosphatidylethanolamines (administration & dosage)
• Plasmalogens (administration & dosage)
• Rats
• Rats, Sprague-Dawley