The roles of CyPA and CD147 in cardiac remodelling.

Abstract

Cyclophilin A (CyPA), an abundantly expressed protein belonging to the immunophilin family, is involved in a variety of physiological and pathological activities together with its extracellular receptor, CD147. Many studies have provided compelling evidence supporting critical roles of CyPA in immune and infectious diseases and malignant tumours. Recent studies have revealed that both CyPA and CD147 strongly promote cardiovascular inflammation, myocardial ischaemia-reperfusion injury, and myocardial remodelling processes. Here, we review the potential roles of CyPA and CD147 in cardiac remodelling and their implications for the development of novel pharmacological therapies for heart failure.

• Authors: Hongyan Su, Yi Yang
• Journal: Experimental and molecular pathology (Exp Mol Pathol) Vol. 104 Issue 3 Pg. 222-226 (06 2018) ISSN: 1096-0945 [Electronic] Netherlands
• PMID: 29772453 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• Basigin
• Cyclophilin A

Topics

• Animals
• Basigin (metabolism)
• Cardiovascular Diseases (metabolism, pathology)
• Cyclophilin A (metabolism)
• Humans
• Inflammation (metabolism, pathology)
• Vascular Remodeling