Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122.

Abstract

We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miR-122 for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form ber-PC. Ber-PC was further electrostatically complexed with miR-122 to yield mr-ber-PC for the co-delivery of BER and miR-122. mr-ber-PC treatment dramatically decreased the level of invasion and migration of OSCC cells compared with single drug treatments. The present study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anticancer drug BER and miR-122 to significantly increase the anticancer therapeutic effects.

• Authors: Lei Li, Xiao Li, Xin Huang, Weilai Jiang, Letian Liu, Chunning Hou, Yanqing Yang, Lei Zhang, Xiaodan Zhang, Longwei Ye, Jie Yuan, Guolin Li, Haiming Sun, Limin Mao
• Journal: Bioscience reports (Biosci Rep) Vol. 38 Issue 3 (06 29 2018) ISSN: 1573-4935 [Electronic] England
• PMID: 29769413 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 The Author(s).

Chemical References

• Antineoplastic Agents, Phytogenic
• Drug Carriers
• MIRN122 microRNA, human
• MicroRNAs
• Berberine
• Polyethyleneimine
• Cholesterol

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Berberine (chemistry, pharmacology)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Cell Proliferation (drug effects)
• Cholesterol (chemistry)
• Diffusion Chambers, Culture
• Drug Carriers
• Drug Compounding (methods)
• Drug Dosage Calculations
• Epithelial Cells (drug effects, metabolism, pathology)
• Humans
• MicroRNAs (genetics, metabolism)
• Nanoparticles (chemistry, metabolism, ultrastructure)
• Polyethyleneimine (chemistry)