Interactions among genes involved in reverse cholesterol transport and in the response to environmental factors in dyslipidemia in subjects from the Xinjiang rural area.

Abstract

Gene-gene and gene-environment interactions may be partially responsible for dyslipidemia, but studies investigating interactions in the reverse cholesterol transport system (RCT) are limited. We explored these interactions in a Xinjiang rural population by genotyping five SNPs using SNPShot technique in APOA1, ABCA1, and LCAT, which are involved in the RCT (690 patients, 743 controls). We conducted unconditional logistical regression analysis to evaluate associations and generalized multifactor dimensionality reduction to evaluate interactions. Results revealed significant differences in rs670 and rs2292318 allele frequencies between cases and controls (P<0.025). rs670 G allele carriers were more likely to develop dyslipidemia than A allele carriers (OR = 1.315, OR 95% CI: 1.067-2.620; P = 0.010). rs2292318 T allele carriers were more likely to develop dyslipidemia than A allele carriers (OR = 1.264, OR 95% CI: 1.037-1.541; P = 0.020). Gene-gene interaction model APOA1rs670-ABCA1rs1800976-ABCA1rs4149313-LCATrs1109166 (P = 0.0107) and gene-environment interaction model ABCA1rs1800976-ABCA1rs4149313-LCATrs1109166-obesity-smoking were optimal dyslipidemia predictors (P = 0.0107) and can interact (4). Differences in A-C-A-C-A and G-G-G-T-G haplotype frequencies were observed (P<0.05). Serum lipid profiles could be partly attributed to RCT gene polymorphisms. Thus, dyslipidemia is influenced by APOA1, ABCA1, LCAT, environmental factors, and their interactions.

• Authors: Xinping Wang, Heng Guo, Yu Li, Haixia Wang, Jia He, Lati Mu, Yunhua Hu, Jiaolong Ma, Yizhong Yan, Shugang Li, Yusong Ding, Mei Zhang, Qiang Niu, Jiaming Liu, Jingyu Zhang, Rulin Ma, Shuxia Guo
• Journal: PloS one (PLoS One) Vol. 13 Issue 5 Pg. e0196042 ( 2018) ISSN: 1932-6203 [Electronic] United States
• PMID: 29758034 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ABCA1 protein, human
• APOA1 protein, human
• ATP Binding Cassette Transporter 1
• Apolipoprotein A-I
• Cholesterol
• Phosphatidylcholine-Sterol O-Acyltransferase

Topics

• ATP Binding Cassette Transporter 1 (genetics)
• Adult
• Apolipoprotein A-I (genetics)
• Case-Control Studies
• China (epidemiology)
• Cholesterol (metabolism)
• Dyslipidemias (epidemiology, genetics, metabolism)
• Epistasis, Genetic
• Female
• Gene-Environment Interaction
• Genotype
• Humans
• Male
• Middle Aged
• Phosphatidylcholine-Sterol O-Acyltransferase (genetics)
• Polymorphism, Single Nucleotide
• Rural Population