1,[Formula: see text]2,[Formula: see text]3,[Formula: see text]4,[Formula: see text]6-Penta-O-Galloyl-β-D-Glucose from Galla rhois Ameliorates Renal Tubular Injury and Microvascular Inflammation in Acute Kidney Injury Rats.

Abstract

Renal ischemia-reperfusion injury (IRI), an important cause of acute kidney injury (AKI), causes increased renal tubular injury and microvascular inflammation. 1,[Formula: see text]2,[Formula: see text]3,[Formula: see text]4,[Formula: see text]6-penta-O-galloyl-[Formula: see text]-D-glucose (PGG) from Galla rhois has anticancer, anti-oxidation and angiogenesis effects. We examined protective effects of PGG on IRI-induced acute AKI. Clamping both renal arteries for 45[Formula: see text]min induced isechemia and then reperfusion. Treatment with PGG (10[Formula: see text]mg/kg/day and 50[Formula: see text]mg/kg/day for four days) significantly ameliorated urine volume, urine osmolality, creatinine clearance (Ccr) and blood urea nitrogen (BUN). In addition, PGG increased aquaporine 1/2/3, Na[Formula: see text]-K[Formula: see text]-ATPase and urea transporter (UT-B) and decreased ICAM-1, MCP-1, and HMGB-1 expression. In this histopathologic study, PGG improved glomerular and tubular damage. Immunohistochemistry results showed that PGG increased aquaporine 1/2, and Na[Formula: see text]-K[Formula: see text] ATPase and decreased ICAM-1 expression. These findings suggest that PGG ameliorates tubular injury including tubular dysfunction and microvascular inflammation in IRI-induced AKI rats.

• Authors: Ji Hun Park, Min Chol Kho, Hyun Cheol Oh, Youn Chul Kim, Jung Joo Yoon, Yun Jung Lee, Dae Gill Kang, Ho Sub Lee
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 46 Issue 4 Pg. 785-800 ( 2018) ISSN: 1793-6853 [Electronic] Singapore
• PMID: 29754505 (Publication Type: Journal Article)

Chemical References

• Aquaporins
• Biological Products
• Galla Rhois
• Hydrolyzable Tannins
• Membrane Transport Proteins
• urea transporter
• Intercellular Adhesion Molecule-1
• pentagalloylglucose
• Creatinine
• Sodium-Potassium-Exchanging ATPase

Topics

• Acute Kidney Injury (drug therapy, etiology, metabolism, prevention & control)
• Animals
• Aquaporins (metabolism)
• Biological Products (chemistry)
• Blood Urea Nitrogen
• Creatinine (metabolism)
• Hydrolyzable Tannins (administration & dosage, isolation & purification)
• Inflammation
• Intercellular Adhesion Molecule-1 (metabolism)
• Kidney (blood supply)
• Kidney Tubules
• Male
• Membrane Transport Proteins (metabolism)
• Metabolic Clearance Rate
• Microvessels
• Phytotherapy
• Rats, Sprague-Dawley
• Reperfusion Injury (complications)
• Sodium-Potassium-Exchanging ATPase (metabolism)