Abstract | Purpose: Patients and methods: Results: Adjusted mean IC after 6-week treatment was 1.990 L with tiotropium/olodaterol vs 1.875 L with tiotropium (difference: 115 mL; 95% CI: 77, 153; p<0.0001). Forced expiratory volume in 1 s (difference: 105 mL; 95% CI: 88, 123), forced vital capacity (difference: 163 mL; 95% CI: 130, 197), and slow vital capacity (difference: 134 mL; 95% CI: 91, 176) improved with tiotropium/olodaterol (all p<0.0001). Adjusted mean 6-min walk distance was similar between treatments in the overall population but was significantly increased with tiotropium/olodaterol in the subgroup with Global Initiative for Chronic Obstructive Lung Disease stage III/IV at baseline (difference: 18.1 m; 95% CI: 2.3, 33.9; p=0.0254). In a post hoc analysis, tiotropium/olodaterol improved the values for ≥2.0 metabolic equivalents (difference: 5.0 min; 95% CI: 0.4, 9.7; p=0.0337). Conclusion:
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Authors | Masakazu Ichinose, Yoshiaki Minakata, Takashi Motegi, Jun Ueki, Yasuhiro Gon, Tetsuo Seki, Tatsuhiko Anzai, Shuhei Nakamura, Kazuto Hirata |
Journal | International journal of chronic obstructive pulmonary disease
(Int J Chron Obstruct Pulmon Dis)
Vol. 13
Pg. 1407-1419
( 2018)
ISSN: 1178-2005 [Electronic] New Zealand |
PMID | 29750027
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Adrenergic beta-2 Receptor Agonists
- Benzoxazines
- Bronchodilator Agents
- Drug Combinations
- Muscarinic Antagonists
- tiotropium-olodaterol
- Tiotropium Bromide
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Topics |
- Adrenergic beta-2 Receptor Agonists
(adverse effects, therapeutic use)
- Adult
- Aged
- Benzoxazines
(adverse effects, therapeutic use)
- Bronchodilator Agents
(adverse effects, therapeutic use)
- Cross-Over Studies
- Double-Blind Method
- Drug Combinations
- Exercise
- Exercise Tolerance
(drug effects)
- Female
- Forced Expiratory Volume
- Health Status
- Humans
- Inspiratory Capacity
- Japan
- Lung
(drug effects, physiopathology)
- Lung Volume Measurements
- Male
- Middle Aged
- Muscarinic Antagonists
(adverse effects, therapeutic use)
- Pulmonary Disease, Chronic Obstructive
(diagnosis, drug therapy, physiopathology)
- Time Factors
- Tiotropium Bromide
(adverse effects, therapeutic use)
- Treatment Outcome
- Walk Test
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