Abstract | BACKGROUND: METHODS: The present study retrospectively examined patients who received neoadjuvant chemotherapy followed by esophagectomy between January 2011 and September 2015. Risk factors for overall survival (OS) were examined by Cox proportional hazard analyses. Pathological responders to neoadjuvant chemotherapy were defined as those with a tumor disappearance of more than one-third of the initial tumor. Postoperative ICs were defined using the Clavien-Dindo classification. RESULTS: Of the 111 patients examined, 45 (40.5%) developed postoperative ICs. A pathological response to neoadjuvant chemotherapy was observed in 54 (48.6%) patients. The multivariate analysis demonstrated that postoperative ICs were a significant independent risk factor for the OS (hazard ratio [HR] 2.359; 95% confidence interval [CI] 1.057-5.263, p = 0.036). In the subset analysis, postoperative ICs were a marginally significant independent risk factor for OS in the nonresponders (HR 2.862; 95% CI 0.942-8.696, p = 0.063) but not in the responders (HR 0.867; 95% CI 0.122-6.153, p = 0.886). CONCLUSIONS:
|
Authors | Kazuki Kano, Toru Aoyama, Takaki Yoshikawa, Yukio Maezawa, Tetsushi Nakajima, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Haruhiko Cho, Takashi Ogata |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 25
Issue 7
Pg. 2034-2043
(Jul 2018)
ISSN: 1534-4681 [Electronic] United States |
PMID | 29748890
(Publication Type: Journal Article)
|
Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carcinoma, Squamous Cell
(mortality, pathology, therapy)
- Chemotherapy, Adjuvant
(mortality)
- Combined Modality Therapy
- Esophageal Neoplasms
(mortality, pathology, therapy)
- Esophagectomy
(mortality)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Neoadjuvant Therapy
(mortality)
- Postoperative Complications
(mortality, pathology, therapy)
- Prognosis
- Retrospective Studies
- Risk Factors
- Surgical Wound Infection
(mortality, pathology, therapy)
- Survival Rate
|