Research Progress on Brucellosis.

Abstract

Brucellosis is a debilitating febrile illness caused by an intracellular Brucella. The disease is distributed in humans and animals widely, especially in developing countries. Ten species are included in the genus Brucella nowadays; four species of them are pathogenic to humans, which make brucellosis a zoonosis with more than 500,000 new cases reported annually. For human brucellosis, the most pathogenic species is B. melitensis followed by B. suis, while B. abortus is the mildest type of brucellosis. The infection mechanism of Brucella is complicated and mostly relies on its virulence factors. The therapy of the disease contains vaccination and antibiotic. However, there are some defects in currently available vaccines such as the lower protective level and safety. Thus, safe and efficient vaccines for brucellosis are still awaited. The dual therapy of antibacterial is effective in the treatment of brucellosis if a rapid and exact detection method is found.

• Authors: Yuming Deng, Xinyue Liu, Kaifang Duan, Qisheng Peng
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 26 Issue 30 Pg. 5598-5608 ( 2019) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 29745323 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Anti-Bacterial Agents
• Bacterial Vaccines

Topics

• Animals
• Anti-Bacterial Agents (chemistry, pharmacology, therapeutic use)
• Bacterial Vaccines (immunology)
• Biomedical Research
• Brucella (drug effects, immunology)
• Brucellosis (immunology, therapy)
• Humans