Effects of caffeic acid phenethyl ester on cisplatin ototoxicity.

Abstract

PURPOSE:

To report histological and electrophysiological data in rats treated with cisplatin and caffeic acid phenethyl ester.

METHODS:

We randomly divided 28 Wistar rats into four groups of seven, to be treated as follows: control (saline), cisplatin, CAPE and cisplatin-CAPE. Distortion product otoacoustic emission (DPOAE) measurements were performed on day one (before drug administration) and day five under anaesthesia. All animals were killed under general anaesthesia on day five after the DPOAE measurement. The cochleae of each rat were histopathologically and immunohistochemically evaluated.

RESULTS:

The outer hair cells were mostly preserved in the control and CAPE groups. Moderate-to-severe and mild-to-moderate hair cell losses were detected in the cisplatin and cisplatin-CAPE groups, respectively. DPOAE assessments revealed significant deterioration in the cisplatin group (P < 0.05). The difference between the cisplatin and cisplatin-CAPE groups was statistically significant (P < 0.05).

CONCLUSION:

CAPE prevents cisplatin ototoxicity.

• Authors: M Ozbay, E Sengul, V Kinis, U Alabalik, B Yilmaz, I Topcu
• Journal: B-ENT (B-ENT) 2016 Vol. 12 Issue 3 Pg. 211-218 ISSN: 1781-782X [Print] Belgium
• PMID: 29727126 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Caffeic Acids
• Cytotoxins
• Caspase 3
• caffeic acid phenethyl ester
• Phenylethyl Alcohol
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Caffeic Acids (pharmacology)
• Caspase 3 (metabolism)
• Cisplatin (pharmacology)
• Cochlea (drug effects, pathology)
• Cytotoxins (pharmacology)
• Hair Cells, Auditory, Outer (drug effects, pathology)
• Microscopy
• Otoacoustic Emissions, Spontaneous (drug effects)
• Phenylethyl Alcohol (analogs & derivatives, pharmacology)
• Random Allocation
• Rats, Wistar