Abstract | OBJECTIVE: METHODS: A multicenter, retrospective department database review was performed to identify patients with stage III nonserous EOC who had undergone maximal or optimal primary CRS followed by six cycles of carboplatin/ paclitaxel chemotherapy at seven gynecological oncology centers in Turkey. Demographic, clinicopathological and survival data were collected. RESULTS: A total of 218 women met the inclusion criteria. Of these, 64 (29.4%) patients had endometrioid, 61 (28%) had mucinous, 54 (24.8%) had clear-cell and 39 (17.9%) had mixed epithelial tumors. Fifty-five (25.2%) patients underwent maximal CRS, whereas 163 (74.8%) had optimal debulking. With a median follow-up of 31.5 months, the 5-year progression-free survival (PFS) and overall survival (OS) rates were 34.8% and 44.2%, respectively. Bilaterality (hazard ratio [HR] 1.44, 95% CI 1.01-2.056; P = 0.04), age (HR 2.25, 95% CI 1.176-4.323; P = 0.014) and maximal cytoreduction (HR 0.34, 95% CI 0.202-0.58; P < 0.001) were found to be independent prognostic factors for PFS. However, age (HR 2.6, 95% CI 1.215-5.591; P = 0.014) and maximal cytoreduction (HR 0.31, 95% CI 0.166-0.615; P < 0.001) were defined as independent prognostic factors for OS. CONCLUSION: The extent of CRS seems to be the only modifiable prognostic factor associated with stage III nonserous EOC. Complete cytoreduction to no gross residual disease should be the main goal of management in these women.
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Authors | Zeliha F Cuylan, Mehmet M Meydanli, Mustafa E Sari, Ozgur Akbayir, Husnu Celik, Murat Dede, Hanifi Sahin, Kemal Gungorduk, Esra Kuscu, Nejat Ozgul, Tayfun Gungor, Ali Ayhan |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 44
Issue 7
Pg. 1284-1293
(Jul 2018)
ISSN: 1447-0756 [Electronic] Australia |
PMID | 29727055
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © 2018 Japan Society of Obstetrics and Gynecology. |
Chemical References |
- Antineoplastic Agents
- Carboplatin
- Paclitaxel
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Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Agents
(administration & dosage, pharmacology)
- Carboplatin
(administration & dosage, pharmacology)
- Carcinoma, Ovarian Epithelial
- Cytoreduction Surgical Procedures
(methods)
- Female
- Humans
- Middle Aged
- Neoplasm Staging
- Neoplasms, Glandular and Epithelial
(diagnosis, drug therapy, mortality, surgery)
- Outcome Assessment, Health Care
- Ovarian Neoplasms
(diagnosis, drug therapy, mortality, surgery)
- Paclitaxel
(administration & dosage, pharmacology)
- Prognosis
- Retrospective Studies
- Young Adult
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