Selenium-Based Nanozyme as Biomimetic Antioxidant Machinery.

Abstract

A self-assembly nanocomposite was designed to mimic intracellular enzymatic and non-enzymatic antioxidants-constituted antioxidant defense machinery. In this work, selenium nanocomponent served as one model to mimic antioxidant enzyme, whereas polydopamine was able to mimic non-enzymatic antioxidant biomolecule in living systems. With the excellent glutathione peroxidase-mimic capacity of selenium and the reducibility of polydopamine, this Se@pDA nanozyme could achieve synergetic antioxidative efficiency to protect cellular components against oxidative damage. The pneumonia model of mice further proved the potential of our nanocomposites for anti-inflammation therapy.

• Authors: Yanyan Huang, Zhen Liu, Chaoqun Liu, Yan Zhang, Jinsong Ren, Xiaogang Qu
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 24 Issue 40 Pg. 10224-10230 (Jul 17 2018) ISSN: 1521-3765 [Electronic] Germany
• PMID: 29722080 (Publication Type: Journal Article)
• Copyright: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.