The subset of patients with acute heart failure able to secrete relaxin-2 at pregnancy concentrations could have a longer survival: a pilot study.

Abstract

OBJECTIVE:

To investigate how many patients with acute heart failure (AHF) hypersecrete relaxin-2 concentrations similar to those of pregnant women and determine their long-term outcome.

METHODS:

In consecutive AHF patients relaxin-2 was quantified by ELISA sandwich method. Patients were divided into pregnancy-like group (PLG, relaxin-2 ≥ 500 pg/mL) and control group (CG, relaxin-2 < 500 pg/mL). The primary outcome was all-cause death during follow-up. Secondary endpoints were prolonged hospitalisation (>10 days), combined endpoint (death, rehospitalisation, ED revisit) 30 days after discharge, and 30-day, one-year and three-year death rates.

RESULTS:

We included 814 patients [81 (SD = 9) years; 53.0% women] followed during 1.9 (SD 2.8) years; 517 (63.5%) died. Twenty patients (2.5%) formed the PLG (median relaxin-2 = 1459 pg/mL; IQR = 1722) and 794 the CG (median = 26; IQR = 44). There was no interaction with variables included on adjustment (age, sex, ischaemic cardiomyopathy, NT-proBNP, glycaemia, and sodium). PLG patients did not have better short-term secondary endpoints, but did show a significantly lower three-year mortality [ORadjusted = 0.17 (0.05-0.5), p = 0.003].

CONCLUSIONS:

The small proportion of AHF patients achieving relaxin-2 concentrations similar to those observed in pregnancy may survive longer.

• Authors: Òscar Miró, Pablo Herrero-Puente, Belén Prieto, María García-García, Pablo García-Hernández, Francisco J Martín-Sánchez, Javier Jacob, José Ríos, Rodolfo Romero, Víctor Gil, Étienne Gayat, Pere Llorens, Alexandre Mebazaa
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 23 Issue 6 Pg. 573-579 (Sep 2018) ISSN: 1366-5804 [Electronic] England
• PMID: 29716428 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Biomarkers
• RLN2 protein, human
• Relaxin

Topics

• Acute Disease
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Female
• Heart Failure (blood, mortality, pathology)
• Humans
• Male
• Pilot Projects
• Pregnancy
• Prospective Studies
• Relaxin (blood)
• Survival Analysis
• Survival Rate