Abstract | AIMS: Coronary artery calcium (CAC) is associated with cardiovascular (CV) disease and progression of CAC is an independent predictor of mortality. Type 1 diabetes is associated with increased CV risk, especially in persons with cardiovascular autonomic neuropathy (CAN). This study aimed to examine whether short-term progression of CAC is increased in persons with type 1 diabetes compared to matched controls and if CAN increases risk of CAC progression. METHODS: Fifty-three normoalbuminuric persons with long-term type 1 diabetes (20 with CAN) were matched in a 1:2 ratio with 106 controls without diabetes according to age, sex and baseline CAC. All were examined twice with cardiac computed tomography scans. Progression of CAC was defined as a value ≥2.5 between the square root-transformed values of follow-up and baseline CAC volume scores. RESULTS: The participants were examined median (interquartile range) of 25 (23-27) months ( type 1 diabetes) and 29 (25-33) months (controls) apart. In multivariable logistic regression, participants with type 1 diabetes had an odds ratio of 3.3 (95% CI 1.3-8.2, p = 0.01) for CAC progression. CAN did not increase progression of CAC (p = 0.64). CONCLUSIONS: Progression of CAC was increased in well-treated, normoalbuminuric persons with type 1 diabetes compared to matched controls without diabetes, suggesting that type 1 diabetes is a risk factor for short-term progression. This finding could explain some of the increased morbidity and mortality observed in persons with type 1 diabetes, but it does not specifically explain the increased CV risk in persons with CAN.
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Authors | Henrik Ø Hjortkjær, Tonny Jensen, Jannik Hilsted, Helle Corinth, Ulrik M Mogensen, Lars Køber, Andreas Fuchs, Børge G Nordestgaard, Klaus F Kofoed |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 141
Pg. 18-25
(Jul 2018)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 29679631
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Calcium
(metabolism)
- Cardiovascular Diseases
(complications, pathology)
- Case-Control Studies
- Coronary Artery Disease
(diagnosis)
- Diabetes Mellitus, Type 1
(complications, pathology)
- Disease Progression
- Early Diagnosis
- Female
- Humans
- Male
- Middle Aged
- Risk Factors
- Serum Albumin
(metabolism)
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