Circadian rhythms of micturition during jet lag.

Abstract

Micturition behavior follows regular day/night fluctuations, and unwanted increase in micturition could occur during night in jet lag condition. To clarify the effect of jet lag on micturition behavior, we simultaneously detected circadian micturition patterns and locomotor activity rhythms of mice under experimental jet lag conditions, by applying the improved automated Voided Stain on Paper (aVSOP) method. When wild-type (WT) mice were phase-advanced for 8 hours, day-night variation of micturition was disrupted suddenly, and this irregular daily micturition continued until 8 days, although their activity rhythms entrained gradually day by day until 8 days. We also examined how jet lag induced changes of micturition in Per-null mice lacking Per1, Per2 and Per3 genes, whose endogenous clock is completely disrupted. We found both micturition and locomotor activity of Per-null mice promptly entrained to the new LD cycle. These findings suggest that the irregular micturition during jet lag is caused along with the gradual shift of the endogenous clock, and paradoxically, jet lag-associated abnormality was absent when endogenous circadian oscillations were genetically disrupted.

• Authors: Kakeru Ito, Miho Yasuda, Yuki Maeda, Jean-Michel Fustin, Yoshiaki Yamaguchi, Yuka Kono, Hiromitsu Negoro, Akihiro Kanematsu, Osamu Ogawa, Masao Doi, Hitoshi Okamura
• Journal: Biomedical research (Tokyo, Japan) (Biomed Res) Vol. 39 Issue 2 Pg. 57-63 ( 2018) ISSN: 1880-313X [Electronic] Japan
• PMID: 29669984 (Publication Type: Journal Article)

Chemical References

• Period Circadian Proteins

Topics

• Animals
• Behavior, Animal
• Circadian Clocks
• Circadian Rhythm
• Disease Models, Animal
• Jet Lag Syndrome (genetics, physiopathology)
• Locomotion
• Male
• Mice
• Mice, Knockout
• Motor Activity
• Period Circadian Proteins (genetics, metabolism)
• Urination