Abstract | OBJECTIVE: Maternal hypothyroidism during pregnancy can affect the neurodevelopment of their offspring. This study aimed to investigate the effects of maternal subclinical hypothyroidism (SCH) on spatial learning and memory, and its relationship with the apoptotic factors in cerebral cortex of the offspring. METHODS: RESULTS: The Pups in the SCH and OH groups showed longer escape latencies in the MWM and decreased field-excitatory post synaptic potentials in LTP tests compared with those in the CON group. p75NTR, p-JNK, p53 and Bax expression levels in the cerebral cortex increased in pups in the SCH and OH groups compared with those in the CON group. CONCLUSIONS: Maternal SCH during pregnancy may impair spatial learning and memory in the offspring and may be associated with the increased apoptosis in the cerebral cortex.
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Authors | Fan Zhang, Jian Chen, Xinyue Lin, Shiqiao Peng, Xiaohui Yu, Zhongyan Shan, Weiping Teng |
Journal | Endocrine connections
(Endocr Connect)
Vol. 7
Issue 5
Pg. 688-697
(May 2018)
ISSN: 2049-3614 [Print] England |
PMID | 29669804
(Publication Type: Journal Article)
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Copyright | © 2018 The authors. |