Abstract | BACKGROUND:
Anticoagulant rodenticides have been widely used in rodent control in China for >30 years and resistant Norway rats have been reported. Mutations in the vitamin K epoxide reductase complex, subunit 1 (Vkorc1) gene can cause anticoagulant resistance in rodents. In this study, we analyzed the Vkorc1 polymorphisms of 681 Norway rats collected in Zhanjiang and Harbin Cities in China from 2008 to 2015 and evaluated the warfarin resistance frequency. RESULTS: Analysis revealed four mutations, including three not previously reported. Two new synonymous mutations, His68His and Leu105Leu, are not associated with warfarin resistance. One new nonsynonymous mutation, Ala140Thr, was found in Zhanjiang rat samples collected in 3 years with low frequencies (3.3-4.0%) and is probably associated with warfarin resistance. Laboratory resistance tests suggested low warfarin resistance frequencies in rats from Zhanjiang (4.9-17.1%) and Harbin (0-2.5%) Cities. CONCLUSIONS:
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Authors | Xiaohui Ma, Dawei Wang, Ning Li, Lan Liu, Lin Tian, Chan Luo, Lin Cong, Zhiyong Feng, Xiao-Hui Liu, Ying Song |
Journal | Pest management science
(Pest Manag Sci)
Vol. 74
Issue 11
Pg. 2555-2560
(Nov 2018)
ISSN: 1526-4998 [Electronic] England |
PMID | 29667309
(Publication Type: Journal Article)
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Copyright | © 2018 Society of Chemical Industry. |
Chemical References |
- Rodenticides
- Warfarin
- VKORC1 protein, rat
- Vitamin K Epoxide Reductases
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Topics |
- Animals
- China
- Cities
- Drug Resistance
(genetics)
- Female
- Male
- Polymorphism, Genetic
(drug effects)
- Rats
(genetics)
- Rodenticides
(pharmacology)
- Time Factors
- Vitamin K Epoxide Reductases
(genetics, metabolism)
- Warfarin
(pharmacology)
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