Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Astragalus membranaceus which was originally described in the Shennong's Classic of Materia Medica, the earliest complete Pharmacopoeia of China written from the Warring States Period to Han Dynasty, has been widely used in Chinese medicine for > 2000 years, especially in the prescription of curing cancer. A. membranaceus has various bioactivities, such as anti- tumor, anti-viral, anti-oxidant, anti-diabetes, anti- inflammation, anti- atherosclerosis, immunomodulation, hepatoprotection, hematopoiesis, neuroprotection and so on. As an important component of A. membranaceus, whether formononetin has a close relationship with its tumor-inhibiting effect on ovarian cancer cell has been investigated. AIM OF STUDY: The present study aimed to demonstrate the anti-proliferation, anti- migration and invasion effects of formononetin on ovarian cancer cells and further explore the underlying molecular mechanisms associated with apoptosis, migration and invasion. MATERIALS AND METHODS: RESULTS: CONCLUSIONS: The present results demonstrated that formononetin have potential effects on induction of apoptosis and suppression of migration and invasion.
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Authors | Jing Zhang, Likun Liu, Jing Wang, Baoyin Ren, Lin Zhang, Weiling Li |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 221
Pg. 91-99
(Jul 15 2018)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 29660466
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Apoptosis Regulatory Proteins
- Isoflavones
- formononetin
- Extracellular Signal-Regulated MAP Kinases
- MMP2 protein, human
- Matrix Metalloproteinase 2
- MMP9 protein, human
- Matrix Metalloproteinase 9
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Topics |
- Antineoplastic Agents
(pharmacology)
- Apoptosis Regulatory Proteins
(metabolism)
- Astragalus propinquus
- Cell Line, Tumor
- Cell Movement
(drug effects)
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Extracellular Signal-Regulated MAP Kinases
(metabolism)
- Female
- Humans
- Isoflavones
(pharmacology)
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Membrane Potential, Mitochondrial
(drug effects)
- Ovarian Neoplasms
(drug therapy, metabolism, pathology)
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