Abstract | OBJECTIVE: METHODS: We examined the relationship of serum periostin levels with clinical features, biomarkers for eosinophilic airway inflammation, fraction of exhaled nitric oxide (FeNO) levels and blood eosinophil counts, and pulmonary functions in 235 well-controlled asthmatic patients on inhaled corticosteroids (ICS) treatment. RESULTS: Serum periostin levels were positively correlated with blood eosinophil counts (%) and age (r = 0.36 and 0.23, respectively), and were negatively correlated with body weight and FEV1/FVC (%) (r = -0.24 and - 0.23, respectively) in well-controlled asthmatic patients on ICS treatment (daily dose of 453 µg equivalent to fluticasone propionate). Blood eosinophil counts and serum periostin levels were similarly associated with increased FeNO levels (≥40 ppb) in the asthmatics. Serum periostin levels were better associated with fixed airflow limitation (FEV1/FVC ratio <70%) than FeNO levels, blood eosinophil counts or total IgE levels in the asthmatics. Multivariate analysis showed that fixed airflow limitation was significantly associated with high serum periostin levels (≥97 ng/ml) (Odds ratio 3.2). CONCLUSIONS: Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics on ICS treatment.
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Authors | Kentaro Takahashi, Kazuyuki Meguro, Hirotoshi Kawashima, Daisuke Kashiwakuma, Shin-Ichiro Kagami, Shoichiro Ohta, Junya Ono, Kenji Izuhara, Itsuo Iwamoto |
Journal | The Journal of asthma : official journal of the Association for the Care of Asthma
(J Asthma)
Vol. 56
Issue 3
Pg. 236-243
(03 2019)
ISSN: 1532-4303 [Electronic] England |
PMID | 29648484
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenal Cortex Hormones
- Biomarkers
- Cell Adhesion Molecules
- POSTN protein, human
- Nitric Oxide
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Topics |
- Administration, Inhalation
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Adult
- Aged
- Airway Remodeling
(physiology)
- Asthma
(blood, drug therapy, physiopathology)
- Biomarkers
- Cell Adhesion Molecules
(biosynthesis, blood)
- Enzyme-Linked Immunosorbent Assay
- Eosinophils
(metabolism)
- Female
- Humans
- Inflammation
(blood, physiopathology)
- Male
- Middle Aged
- Nitric Oxide
(analysis)
- Respiratory Function Tests
- Retrospective Studies
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