Abstract | Background:
Biologic therapy has revolutionized the management of refractory chronic autoimmune and auto-inflammatory disease, as well as several malignancies, providing rapid symptomatic relief and/or disease remission. Patients receiving biologic therapies have an improved quality of life, facilitating travel to exotic destinations and potentially placing them at risk of a range of infections. For each biologic agent, we review associated travel-related infection risk and expected travel vaccine response and effectiveness. Methods: A PUBMED search [vaccination OR vaccine] AND/OR ['specific vaccine'] AND/OR [immunology OR immune response OR response] AND [ biologic OR biological OR biologic agent] was performed. A review of the literature was performed in order to develop recommendations on vaccination for patients in receipt of biologic therapy travelling to high-risk travel destinations. Results: Conclusions: Best practice requires a collaborative approach between the patient's primary healthcare physician, relevant specialist and travel medicine expert, who should all be familiar with the immunosuppressive and immunomodulatory effects resulting from the biologic therapies. Timing of vaccines should be carefully planned, and if possible, vaccination provided well before established immunosuppression.
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Authors | Victoria Hall, Douglas Johnson, Joseph Torresi |
Journal | Journal of travel medicine
(J Travel Med)
Vol. 25
Issue 1
(01 01 2018)
ISSN: 1708-8305 [Electronic] England |
PMID | 29635641
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Biological Factors
(therapeutic use)
- Communicable Disease Control
(methods)
- Humans
- Immunocompromised Host
(immunology)
- Quality of Life
- Risk
- Travel-Related Illness
- Vaccination
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