Thromboelastography Before Epidural Placement in a Thrombocytopenic Parturient With Gaucher Disease Treated With Imiglucerase: A Case Report.

Abstract

Gaucher disease is a common inborn error of metabolism leading to widespread chronic inflammation and often thrombocytopenia. Here we discuss assessment of coagulation in a parturient with Gaucher disease treated with imiglucerase, who presented with thrombocytopenia and requested epidural analgesia for planned vaginal delivery. We used thromboelastography to determine the safety of placing an epidural catheter and to plan for potential peripartum bleeding. The patient had a normal coagulation profile by thromboelastography and had uncomplicated epidural analgesia for a successful spontaneous vaginal delivery.

• Authors: William G Tharp, Borzoo Farhang
• Journal: A&A practice (A A Pract) Vol. 11 Issue 1 Pg. 16-18 (Jul 01 2018) ISSN: 2575-3126 [Electronic] United States
• PMID: 29634566 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucosylceramidase
• imiglucerase

Topics

• Adult
• Analgesia, Epidural (methods)
• Analgesia, Obstetrical (methods)
• Delivery, Obstetric
• Enzyme Replacement Therapy (methods)
• Female
• Gaucher Disease (drug therapy, genetics)
• Glucosylceramidase (therapeutic use)
• Humans
• Pregnancy
• Pregnancy Complications (prevention & control)
• Purpura, Thrombocytopenic
• Thrombelastography