Abstract | OBJECTIVE: METHODS: This US commercial claims analysis (4 April 2010 through 24 September 2014) used the Optum Research Database to identify adult patients with bipolar disorder treated with oral atypical antipsychotics (N = 11,132). The first claim for an atypical antipsychotic defined the index date, with pre-index and post-index periods of 180 and 360 days, respectively. Every month of the post-index period was categorized as monotherapy treatment with lurasidone, aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone, no/minimal treatment or other. Starting with the initial month of treatment, the risk of psychiatric or all-cause hospitalization in the subsequent month was examined based on treatment in the current month and pre-index covariates (age, gender, hospitalizations, emergency room visits, diagnoses for anxiety, alcohol abuse, substance abuse, hypertension, type 2 diabetes and obesity) and time-varying versions of the pre-index covariates using a marginal structural model. RESULTS: After controlling for covariates, relative to lurasidone, the odds of psychiatric and all-cause hospitalization, respectively, were 2-3 times higher for olanzapine (odds ratio [OR] = 2.78, CI 1.09, 7.08, p = .032; OR = 3.20, CI 1.24, 8.26, p = .016), quetiapine (OR = 2.80, CI 1.13, 6.95, p = .026; OR = 3.23, CI 1.29, 8.11, p = .013), risperidone (OR = 2.50, CI 1.01, 6.21, p = .048; OR = 2.79, CI 1.11, 7.02, p = .029), aripiprazole (OR = 2.13, CI 0.87, 5.20, p = .097; OR = 2.57, CI 1.04, 6.37, p = .041) and ziprasidone (OR =2.31, CI 0.91, 5.85, p = .079; OR = 2.49, CI 0.97, 6.40, p = .058). CONCLUSIONS:
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Authors | Daisy Ng-Mak, Rachel Halpern, Krithika Rajagopalan, Antony Loebel |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 35
Issue 2
Pg. 211-219
(02 2019)
ISSN: 1473-4877 [Electronic] England |
PMID | 29625538
(Publication Type: Comparative Study, Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Lurasidone Hydrochloride
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Topics |
- Adult
- Antipsychotic Agents
(therapeutic use)
- Bipolar Disorder
(drug therapy)
- Databases, Factual
- Female
- Hospitalization
(statistics & numerical data)
- Humans
- Lurasidone Hydrochloride
(therapeutic use)
- Male
- Retrospective Studies
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