Abstract | OBJECTIVE: METHODS: Patients diagnosed with DSM-IV schizophrenia and under clozapine or olanzapine monotherapy for at least six months were recruited. We used the modified ATP III criteria for Asians to evaluate subjects for a diagnosis of MetS. RESULTS: We recruited 262 study subjects with schizophrenia, and classified them into those with MetS (n = 87) and those without MetS (n = 175). Leptin level was positively correlated with BMI, waist circumference, and insulin level. Adiponectin level was negatively correlated with most metabolic parameters, except glucose level. L/A ratio was positively correlated with most metabolic parameters, except levels of glucose and HDL-C. Significant gender differences existed in leptin levels, adiponectin levels, and L/A ratio. Without and with adjustment of age and gender, binary logistic regression analysis showed that leptin level, adiponectin level, and L/A ratio were significantly associated with MetS. The area under curve (AUC) of L/A ratio and leptin level for MetS was 0.744 (95% CI = 0.685-0.802) and 0.666 (95% CI = 0.601-0.731). The AUC of adiponectin level for the absence of MetS was 0.717 (95% CI = 0.655-0.780). The discriminative strength of L/A ratio for MetS was better in men than in women. CONCLUSIONS:
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Authors | Vincent Chin-Hung Chen, Chun-Hsin Chen, Yi-Hang Chiu, Tsang-Yaw Lin, Feng-Chiao Li, Mong-Liang Lu |
Journal | Psychoneuroendocrinology
(Psychoneuroendocrinology)
Vol. 92
Pg. 34-40
(06 2018)
ISSN: 1873-3360 [Electronic] England |
PMID | 29625373
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
- ADIPOQ protein, human
- Adipokines
- Adiponectin
- Biomarkers
- Leptin
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Topics |
- Adipokines
- Adiponectin
(analysis, blood)
- Adult
- Biomarkers
(blood)
- Body Mass Index
- Female
- Humans
- Leptin
(analysis, blood)
- Male
- Metabolic Syndrome
(diagnosis, metabolism)
- Middle Aged
- Schizophrenia
(metabolism)
- Sex Factors
- Waist Circumference
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