Abstract | OBJECTIVE:
Polycystic ovary syndrome (PCOS) is a complex condition which can include menstrual irregularity, metabolic derangement, and increased androgen levels. The mechanism of PCOS is unknown. Some suggest that excess production of androgens by the ovaries may cause or exacerbate the metabolic findings. The purpose of this study was to assess the role of increased testosterone on metabolic parameters for individuals presumed to be chromosomally female by examination of these parameters in hormone-treated transgender men. METHODS: In 2015 and 2016, we asked all transgender men who visited the Endocrinology Clinic at Boston Medical Center treated with testosterone for consent for a retrospective anonymous chart review. Of the 36 men, 34 agreed (94%). Serum metabolic factors and body mass index (BMI) levels for each patient were graphed over time, from initiation of therapy through 6 years of treatment. Bivariate analyses were conducted to analyze the impact of added testosterone. RESULTS: CONCLUSION:
Testosterone therapy in transgender men across a wide range of doses and over many years did not result in the dyslipidemia or abnormalities in HbA1c seen with PCOS. Instead, treatment of transgender men with testosterone resulted only in a shift of metabolic biomarkers toward the average physiologic male body. ABBREVIATIONS:
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Authors | Kelly J Chan, Jennifer J Liang, Divya Jolly, Jamie D Weinand, Joshua D Safer |
Journal | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
(Endocr Pract)
Vol. 24
Issue 6
Pg. 565-572
(Jun 2018)
ISSN: 1530-891X [Print] United States |
PMID | 29624102
(Publication Type: Journal Article)
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Chemical References |
- Cholesterol, LDL
- Glycated Hemoglobin A
- hemoglobin A1c protein, human
- Testosterone
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Topics |
- Adolescent
- Adult
- Aged
- Body Mass Index
- Cholesterol, LDL
(blood)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Male
- Middle Aged
- Polycystic Ovary Syndrome
(metabolism)
- Testosterone
(therapeutic use)
- Transgender Persons
- Young Adult
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