HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anti-Inflammatory Activity of Epimedium brevicornu Maxim Ethanol Extract.

Abstract
Epimedium brevicornu Maxim has been used as a traditional herbal drug in China. In this study, the anti-inflammatory effects of E. brevicornu Maxim ethanol extract (EBME) were investigated in RAW264.7 macrophages and mice challenged with lipopolysaccharide (LPS). Results showed that EBME attenuated inflammation by decreasing the production of several proinflammatory mediators, such as nitric oxide (NO), prostaglandin (PG) E2, inducible nitric oxide synthase, and cyclooxygenase-2, in LPS-stimulated RAW264.7 macrophages. EBME increased the expression of heme oxygenase-1 (HO-1) and promoted the nuclear translocation of nuclear factor erythroid 2-related factor 2. The inhibitory effects of EBME on LPS-stimulated NO and PGE2 expression were partially reversed by HO-1 inhibitor. EBME also elicited an anti-inflammatory effect by inhibiting the production of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in LPS-induced peritonitis. Therefore, EBME exhibited anti-inflammatory effects in vitro and in vivo.
AuthorsShan Huang, Ning Meng, Bingquan Chang, Xianghua Quan, RuiYing Yuan, Bin Li
JournalJournal of medicinal food (J Med Food) Vol. 21 Issue 7 Pg. 726-733 (Jul 2018) ISSN: 1557-7600 [Electronic] United States
PMID29620952 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Interleukin-6
  • NF-E2-Related Factor 2
  • Plant Extracts
  • Nitric Oxide
  • Heme Oxygenase-1
  • Dinoprostone
Topics
  • Animals
  • Anti-Inflammatory Agents (administration & dosage, analysis, isolation & purification)
  • Dinoprostone (immunology)
  • Epimedium (chemistry)
  • Heme Oxygenase-1 (genetics, immunology)
  • Humans
  • Interleukin-6 (genetics, immunology)
  • Macrophages (drug effects, immunology)
  • Male
  • Mice
  • NF-E2-Related Factor 2 (genetics, immunology)
  • Nitric Oxide (immunology)
  • Peritonitis (drug therapy, genetics, immunology)
  • Plant Extracts (administration & dosage, analysis, isolation & purification)
  • RAW 264.7 Cells

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: