Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study.

Abstract

Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM10 and PM2.5), road traffic, and ozone (O3) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence.The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00-1.18) per 5000 vehicles per day), with O3 exposure (aOR 2.04 (95% CI 1.27-3.29) per 10 µg·m-3) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06-2.12) per 1 pg·mL-1). Among participants without asthma, exhaled 8-iso concentration increased with PM2.5 exposure (adjusted (a)β 0.23 (95% CI 0.005-0.46) per 5 µg·m-3), and decreased with O3 and O3-summer exposures (aβ -0.20 (95% CI -0.39- -0.01) and aβ -0.52 (95% CI -0.77- -0.26) per 10 µg·m-3, respectively).Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.

• Authors: Anaïs Havet, Farid Zerimech, Margaux Sanchez, Valérie Siroux, Nicole Le Moual, Bert Brunekreef, Morgane Stempfelet, Nino Künzli, Bénédicte Jacquemin, Régis Matran, Rachel Nadif
• Journal: The European respiratory journal (Eur Respir J) Vol. 51 Issue 4 (04 2018) ISSN: 1399-3003 [Electronic] England
• PMID: 29618600 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright ©ERS 2018.

Chemical References

• Air Pollutants
• Biomarkers
• Particulate Matter
• 8-epi-prostaglandin F2alpha
• Dinoprost

Topics

• Adult
• Aged
• Air Pollutants (analysis)
• Asthma (epidemiology)
• Biomarkers (analysis)
• Breath Tests
• Case-Control Studies
• Cross-Sectional Studies
• Dinoprost (analogs & derivatives, analysis)
• Environmental Exposure (adverse effects)
• Exhalation
• Female
• France (epidemiology)
• Humans
• Linear Models
• Male
• Middle Aged
• Oxidative Stress
• Particulate Matter (analysis)
• Young Adult