Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial.

Abstract

Background:

Although trichuriasis affects millions of children worldwide, recommended drugs lack efficacy and new treatment options are urgently needed. Ivermectin has promising potential to complement the anthelminthic armamentarium.

Methods:

A randomized placebo-controlled trial was conducted in rural Côte d'Ivoire to provide evidence on the efficacy and safety of ascending oral ivermectin dosages in preschool-aged children (PSAC) and school-aged children (SAC) infected with Trichuris trichiura. The primary outcome was the cure rate (CR) for T. trichiura infection, and the secondary outcomes were safety, egg-reduction rates (ERRs) against T. trichiura infection, and CRs and ERRs against other soil-transmitted helminth species.

Results:

A total of 126 PSAC and 166 SAC were included in an available case analysis. In PSAC, efficacy against T. trichiura did not differ between 200 µg/kg ivermectin and placebo treatment arm, as expressed in CRs (20.9% [95% confidence interval {CI}, 11.9%-52.8%] vs 19.5% [10.4%-49.9%]) and geometric mean ERRs (78.6% [60.1%-89.5%] vs 68.2% [40.5%-84.8%]). In SAC, the highest administered ivermectin dose of 600 µg/kg had a low CRs (12.2% [95% CI, 4.8%-32.3%]) and moderate ERRs (66.3% [43.8%-80.2%]). Only mild adverse events and no organ toxicity, based on serum biomarkers, was observed.

Conclusion:

Ivermectin can be administered safely to PSAC with trichuriasis. Given the low efficacy of ivermectin monotherapy against T. trichiura infection, further research should investigate the optimal drug combinations and dosages with ivermectin against soil-transmitted helminthiasis.

Clinical Trials Registration:

ISRCTN15871729 (www.isrctn.com).

• Authors: David Wimmersberger, Jean T Coulibaly, Jessica D Schulz, Maxim Puchkow, Jörg Huwyler, Yves N'Gbesso, Jan Hattendorf, Jennifer Keiser
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 67 Issue 8 Pg. 1247-1255 (09 28 2018) ISSN: 1537-6591 [Electronic] United States
• PMID: 29617737 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Ivermectin

Topics

• Animals
• Anthelmintics (administration & dosage, adverse effects)
• Child
• Child, Preschool
• Cote d'Ivoire
• Dose-Response Relationship, Drug
• Feces (parasitology)
• Female
• Humans
• Ivermectin (administration & dosage, adverse effects)
• Male
• Parasite Egg Count
• Treatment Outcome
• Trichuriasis (drug therapy)
• Trichuris (drug effects)