Abstract | INTRODUCTION: OBJECTIVES: This study compared clinical and economic outcomes between patients with and without PD program participation. METHODS: This retrospective study included commercial and Medicare Advantage health insurance plan members with ≥ 1 claim with diagnosis codes for COPD and ≥ 1 medical or pharmacy claim including A1PI (on index date). Outcomes were compared between patients receiving only Prolastin® or Prolastin®-C (PD cohort) and patients who received a different brand without PD (Comparator cohort). Demographic and clinical characteristics were captured during 6 months pre-index. Post-index exacerbation episodes and healthcare utilization and costs were compared between cohorts. RESULTS: The study sample comprised 445 patients (n = 213 in PD cohort; n = 232 in Comparator cohort), with a mean age 55.5 years, 50.8% male, and 78.9% commercially insured. The average follow-up was 822 days (2.25 years), and the average time on A1PI was 747 days (2.04 years). Few differences were observed in demographic or clinical characteristics. Adjusting for differences in patient characteristics, the rate of severe exacerbation episodes was reduced by 36.1% in the PD cohort. Adjusted total annual all-cause costs were 11.4% lower, and adjusted mean respiratory-related costs were 10.6% lower in the PD cohort than the Comparator cohort. Annual savings in all-cause total costs in the PD cohort relative to the Comparator cohort was US$25,529 per patient, largely due to significantly fewer and shorter hospitalizations. CONCLUSIONS: These results suggest that comprehensive health management services may improve both clinical and economic outcomes among patients with COPD and AATD who receive augmentation therapy. FUNDING: Grifols Shared Services of North America, Inc.
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Authors | Michael A Campos, Michael C Runken, Angela M Davis, Michael P Johnson, Glenda A Stone, Ami R Buikema |
Journal | Advances in therapy
(Adv Ther)
Vol. 35
Issue 4
Pg. 467-481
(04 2018)
ISSN: 1865-8652 [Electronic] United States |
PMID | 29616482
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Trypsin Inhibitors
- alpha 1-Antitrypsin
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Topics |
- Aged
- Cohort Studies
- Cost-Benefit Analysis
- Costs and Cost Analysis
- Disease Management
- Female
- Hospitalization
(economics)
- Humans
- Insurance Claim Review
(statistics & numerical data)
- Male
- Middle Aged
- Patient Education as Topic
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
- Retrospective Studies
- Trypsin Inhibitors
(therapeutic use)
- alpha 1-Antitrypsin
(economics, therapeutic use)
- alpha 1-Antitrypsin Deficiency
(drug therapy)
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