Kinetics Are Crucial When Targeting Copper Ions to Fight Alzheimer's Disease: An Illustration with Azamacrocyclic Ligands.

Abstract

Targeting copper ions to either remove or redistribute them is currently viewed as a possible therapeutic strategy in the context of Alzheimer's disease (AD). Thermodynamic parameters, as for instance the copper(II) affinity of the drug candidate or the copper(II) over zinc(II) selectivity, are considered in the design of the drug candidate. In contrast, kinetic factors have been overlooked despite their probable high importance. In the present article, we use a series of azamacrocyclic ligands to demonstrate that kinetic issues must be taken into account when designing copper-targeting drug candidates in the context of AD.

• Authors: Amandine Conte-Daban, Maryline Beyler, Raphaël Tripier, Christelle Hureau
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 24 Issue 33 Pg. 8447-8452 (Jun 12 2018) ISSN: 1521-3765 [Electronic] Germany
• PMID: 29611877 (Publication Type: Journal Article)
• Copyright: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Aza Compounds
• Coordination Complexes
• Ligands
• Copper
• Zinc

Topics

• Alzheimer Disease (drug therapy)
• Aza Compounds (chemistry)
• Coordination Complexes (chemistry)
• Copper (chemistry)
• Humans
• Kinetics
• Ligands
• Thermodynamics
• Zinc (chemistry)