Abstract | BACKGROUND: MRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models. PURPOSE: To compare the effects on liver tissue of gadolinium-based MRI contrast agents in the light of biochemical and histopathological evaluation. STUDY TYPE: Institutional Review Board (IRB)-approved controlled longitudinal study. ANIMAL MODEL: In all, 32 male Sprague-Dawley rats were divided into a healthy control group subjected to no procedure (Group 1), a sham group (Group 2), a gadodiamide group (Group 3), and a gadoteric acid group (Group 4). FIELD STRENGTH/SEQUENCE: Not applicable. ASSESSMENT: Liver tissues removed at the end of the fifth week and evaluated pathologically (scored Knodell's histological activity index [HAI] method by two histopathologists) immunohistochemical ( caspase-3 and biochemical tests (AST, ALT, TAS, TOS, and OSI method by Erel et al) were obtained. STATISTICAL TESTS: Differences between groups were analyzed using the nonparametric Kruskal-Wallis test followed by the Tamhane test, and one-way analysis of variance (ANOVA) followed by Turkey's HSD test. RESULTS: An increase was observed in histological activity scores in sections from rats administered gadodiamide and gadoteric acid, and in caspase-3, AST and ALT values (P < 0.05). In contrast, we determined no change in TOS (P = 0.568 and P = 0.094, respectively), TAS (P = 0.151 and P = 0.055, respectively), or OSI (P = 0.949 and P = 0.494, respectively) values. DATA CONCLUSION: LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2018;47:1367-1374.
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Authors | Tolga Mercantepe, Levent Tümkaya, Fatma Beyazal Çeliker, Zehra Topal Suzan, Seda Çinar, Kerimali Akyildiz, Filiz Mercantepe, Adnan Yilmaz |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
Vol. 48
Issue 5
Pg. 1367-1374
(11 2018)
ISSN: 1522-2586 [Electronic] United States |
PMID | 29607566
(Publication Type: Journal Article)
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Copyright | © 2018 International Society for Magnetic Resonance in Medicine. |
Chemical References |
- Antioxidants
- Contrast Media
- gadodiamide
- Gadolinium
- Caspase 3
- Gadolinium DTPA
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Topics |
- Animals
- Antioxidants
(chemistry)
- Apoptosis
- Caspase 3
(metabolism)
- Contrast Media
(chemistry)
- Gadolinium
(chemistry)
- Gadolinium DTPA
(chemistry)
- Hepatocytes
(drug effects)
- Liver
(diagnostic imaging)
- Longitudinal Studies
- Magnetic Resonance Imaging
- Male
- Necrosis
- Rats
- Rats, Sprague-Dawley
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