Abstract |
Because of its ability to increase glomerular filtration, antagonize the actions of vasoconstrictors, and produce vasodilation, alpha human atrial natriuretic peptide ( alpha-hANP) was evaluated for its potentially beneficial effects in experimental ischemic renal failure induced by 45-60 min of renal artery occlusion in bilaterally or unilaterally renally intact Sprague-Dawley rats. After ischemia, a 4-h intrarenal infusion of alpha-hANP restored 14C-inulin clearances in bilaterally and unilaterally intact animals from 0.05 +/- 0.006 and 0.05 +/- 0.01 ml/min per 100 g to 0.314 +/- 0.04 and 0.25 +/- 0.01 ml/min per 100 g, respectively (P less than 0.001, n = 8), compared with normal values of 0.49 +/- 0.023 ml/min per 100 g. Histologically, there was a progressive decrease in medullary hyperemia and prevention of intratubular cell shedding and granulocyte margination as a result of the 4-h alpha-hANP infusion such that after 24 and 48 h the histological appearance of the tissue was essentially normal. The results show that a 4-h intrarenal infusion of alpha-hANP after renal ischemia can preserve glomerular filtration rate and reduce renal tissue damage.
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Authors | S G Shaw, P Weidmann, J Hodler, A Zimmermann, A Paternostro |
Journal | The Journal of clinical investigation
(J Clin Invest)
Vol. 80
Issue 5
Pg. 1232-7
(Nov 1987)
ISSN: 0021-9738 [Print] United States |
PMID | 2960693
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Atrial Natriuretic Factor
- Inulin
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Topics |
- Acute Kidney Injury
(pathology, physiopathology, prevention & control)
- Animals
- Atrial Natriuretic Factor
(therapeutic use)
- Constriction
- Disease Models, Animal
- Female
- Glomerular Filtration Rate
- Inulin
(pharmacokinetics)
- Ischemia
(complications)
- Kidney
(blood supply, pathology, physiopathology)
- Rats
- Rats, Inbred Strains
- Renal Artery
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