Human S-cone electroretinograms obtained by silent substitution stimulation.

Abstract

We used triple silent substitution stimuli to characterize human S-cone electroretinograms (ERGs) in normal trichromats. Short-wavelength-cone (S-cone) ERGs were found to have different morphological features and temporal frequency response characteristics compared to ERGs derived from L-cones, M-cones, and rod photoreceptors in normal participants. Furthermore, in two cases of retinal pathology, blue cone monochromatism (BCM) and enhanced S-cone syndrome (ESCS), S-cone ERGs elicited by our stimuli were preserved and enhanced, respectively. The results from both normal and pathological retinae demonstrate that triple silent substitution stimuli can be used to generate ERGs that provide an assay of human S-cone function.

• Authors: J Maguire, N R A Parry, J Kremers, I J Murray, D McKeefry
• Journal: Journal of the Optical Society of America. A, Optics, image science, and vision (J Opt Soc Am A Opt Image Sci Vis) Vol. 35 Issue 4 Pg. B11-B18 (Apr 01 2018) ISSN: 1520-8532 [Electronic] United States
• PMID: 29603933 (Publication Type: Journal Article)

Chemical References

• Cone Opsins

Topics

• Adult
• Color Vision Defects (physiopathology)
• Cone Opsins (physiology)
• Electroretinography
• Eye Diseases, Hereditary (physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Photic Stimulation
• Retinal Cone Photoreceptor Cells (physiology)
• Retinal Degeneration (physiopathology)
• Vision Disorders (physiopathology)
• Young Adult