Abstract |
Development of versatile nanoscale platforms for cancer diagnosis and therapy is of great importance for applications in translational medicine. In this work, we present the use of γ- polyglutamic acid (γ- PGA) nanogels (NGs) to load polypyrrole (PPy) for thermal/photoacoustic (PA) imaging and radiotherapy (RT)-sensitized tumor photothermal therapy (PTT). First, a double emulsion approach was used to prepare the cystamine dihydrochloride (Cys)-cross-linked γ- PGA NGs. Next, the cross-linked NGs served as a reactor to be filled with pyrrole monomers that were subjected to in situ oxidation polymerization in the existence of Fe(III) ions. The formed uniform PPy-loaded NGs having an average diameter of 38.9 ± 8.6 nm exhibited good water-dispersibility and colloid stability. The prominent near-infrared (NIR) absorbance feature due to the loaded PPy endowed the NGs with contrast enhancement in PA imaging. The hybrid NGs possessed excellent photothermal conversion efficiency (64.7%) and stability against laser irradiation, and could be adopted for PA imaging and PTT of cancerous cells and tumor xenografts. Importantly, we also explored the cooperative PTT and X-ray radiation-mediated RT for enhanced tumor therapy. We show that PTT of tumors can be more significantly sensitized by RT using the sequence of laser irradiation followed by X-ray radiation as compared to using the reverse sequence. Our study suggests a promising theranostic platform of hybrid NGs that may be potentially utilized for PA imaging and combination therapy of different types of tumors.
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Authors | Yiwei Zhou, Yong Hu, Wenjie Sun, Shiyi Lu, Chao Cai, Chen Peng, Jing Yu, Rachela Popovtzer, Mingwu Shen, Xiangyang Shi |
Journal | Biomacromolecules
(Biomacromolecules)
Vol. 19
Issue 6
Pg. 2034-2042
(06 11 2018)
ISSN: 1526-4602 [Electronic] United States |
PMID | 29601720
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gels
- Polymers
- Pyrroles
- poly(gamma-glutamic acid)
- Polyglutamic Acid
- polypyrrole
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Topics |
- Animals
- Female
- Gels
(administration & dosage, chemistry)
- Mice
- Mice, Inbred BALB C
- Nanostructures
(administration & dosage, chemistry)
- Neoplasms, Experimental
(diagnostic imaging)
- Photoacoustic Techniques
(methods)
- Photochemotherapy
(instrumentation, methods)
- Polyglutamic Acid
(analogs & derivatives, chemistry)
- Polymerization
- Polymers
(chemistry)
- Pyrroles
(chemistry)
- Radiotherapy
(methods)
- X-Rays
- Xenograft Model Antitumor Assays
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