Abstract | INTRODUCTION: Collagenous gastritis is a rare disease characterized by the subepithelial deposition of collagen bands. Two phenotypes of the disease have been described: a pediatric-onset and an adult-onset type. The adult-onset form is associated with collagenous colitis and autoimmune disorders. No effective treatment has been identified to date. OBJECTIVE: We aim to describe the clinical features and outcomes of patients in our cohort and provide a summary of published pediatric cases with collagenous gastritis and colitis reported to date to gather information that will contribute to improved knowledge of this rare condition. METHODS: A retrospective chart review of all patients with collagenous gastritis and/or colitis who were treated at the Royal Children's Hospital, Melbourne, was performed. A literature review was also conducted. RESULTS: CONCLUSIONS: Collagenous gastritis is a rare condition in children. A small proportion of children develop features of the "'adult" phenotype at a very young age. Patients with collagenous gastritis require long-term follow-up and monitoring of their disease. Further randomized clinical trials are needed to establish an effective therapeutic strategy.
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Authors | Judy Matta, George Alex, Donald J S Cameron, Chung W Chow, Winita Hardikar, Ralf G Heine |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 67
Issue 3
Pg. 328-334
(09 2018)
ISSN: 1536-4801 [Electronic] United States |
PMID | 29601434
(Publication Type: Journal Article, Review)
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Chemical References |
- Proton Pump Inhibitors
- Collagen
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Topics |
- Adolescent
- Biopsy
- Child
- Child, Preschool
- Colitis, Collagenous
(diagnosis, physiopathology, therapy)
- Collagen
- Diet
(methods)
- Diet, Gluten-Free
- Endoscopy, Gastrointestinal
(methods)
- Female
- Follow-Up Studies
- Gastric Mucosa
(physiopathology)
- Gastritis
(diagnosis, physiopathology, therapy)
- Humans
- Male
- Proton Pump Inhibitors
(therapeutic use)
- Retrospective Studies
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