Interferon regulatory factor 1 inactivation in human cancer.

Abstract

Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation. The different mechanisms underlying IRF-1 inactivation and their implications for human cancers and the potential importance of IRF-1 in immunotherapy are also summarized.

• Authors: Khaldoon Alsamman, Omar S El-Masry
• Journal: Bioscience reports (Biosci Rep) Vol. 38 Issue 3 (06 29 2018) ISSN: 1573-4935 [Electronic] England
• PMID: 29599126 (Publication Type: Journal Article, Review)
• Copyright: © 2018 The Author(s).

Chemical References

• IRF1 protein, human
• IRF2 protein, human
• Interferon Regulatory Factor-1
• Interferon Regulatory Factor-2

Topics

• Gene Expression Regulation, Neoplastic
• Humans
• Inflammation (genetics, immunology, therapy)
• Interferon Regulatory Factor-1 (antagonists & inhibitors, genetics, immunology)
• Interferon Regulatory Factor-2 (antagonists & inhibitors, genetics, immunology)
• Neoplasms (genetics, immunology, therapy)