The Circadian Rhythm-Related MTNR1B Genotype, Gestational Weight Gain, and Postpartum Glycemic Changes.

Abstract

Context:

Disturbed circadian rhythms and sleep quality during pregnancy have been related to gestational weight gain and gestational diabetes mellitus (GDM), which affect postpartum glucose metabolism and future risk of type 2 diabetes.

Objective:

We assessed whether the circadian rhythm-related melatonin receptor 1B (MTNR1B) genotype was associated with 1 to 5 years of postpartum glycemic changes among women with a history of GDM and whether gestational weight gain modified such associations.

Design, Settings, and Participants:

The established circadian rhythm-associated MTNR1B genetic variant (rs10830963) was genotyped in 1025 Chinese women with a history of GDM. Body weight and glycemic traits, during and after pregnancy, were longitudinally collected.

Main Outcome Measures:

The main outcome measure was postpartum glycemic changes.

Results:

We found that women carrying different MTNR1B genotypes showed distinct postpartum changes in 2-hour oral glucose tolerance test: 0.36, 0.20, and -0.19 mM per additional copy of the shorter sleep duration-related G allele in women with inadequate, adequate, and excessive gestational weight gain, respectively (for interaction, P = 0.028). The corresponding changes in fasting glucose were 0.14, 0.13, and 0.01 mM, although the modification effect of gestational weight gain on the genetic association was marginally significant (for interaction, P = 0.067).

Conclusions:

Our findings suggest that gestational weight gain may modify the circadian rhythm-related MTNR1B genetic variant on long-term glycemic changes, highlighting the significance of gestational weight management in diabetes prevention among women with GDM.

• Authors: Hoirun Nisa, Kevin H T Qi, Junhong Leng, Tao Zhou, Huikun Liu, Weiqin Li, Leishen Wang, Nan Li, Gang Hu, Lu Qi
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 103 Issue 6 Pg. 2284-2290 (06 01 2018) ISSN: 1945-7197 [Electronic] United States
• PMID: 29590381 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• MTNR1B protein, human
• Receptor, Melatonin, MT2

Topics

• Adult
• Alleles
• Blood Glucose (genetics)
• Diabetes, Gestational (genetics)
• Female
• Genotype
• Gestational Weight Gain (genetics)
• Glucose Tolerance Test
• Humans
• Polymorphism, Single Nucleotide
• Postpartum Period
• Pregnancy
• Receptor, Melatonin, MT2 (genetics)
• Retrospective Studies