[Trabeculectomy with mitomycin C : Video article].

Abstract

Trabeculectomy is the most proven method for the treatment of open angle glaucoma. The long-term results of this method show an 80% success rate in lowering intraocular pressure over 20 years. The surgical technique is demonstrated in detail with the help of a video of the operation and which is available online. For more than 15 years trabeculectomy has been performed with the use of antifibrotic substances, such as mitomycin C. Long-term treatment with antiglaucoma eyedrops leads to a proven inflammation of the conjunctiva and the ocular surface with an increase in lymphocytes, mast cells, and fibroblasts. Discontinuation of antiglaucoma therapy in turn allows regeneration of the ocular surface. From the knowledge gained from these histopathological studies it has been recommended to stop glaucoma treatment prior to glaucoma surgery and to pretreat the conjunctiva with eyedrops containing cortisone. Administration of nonsteroidal antiphlogistic substances or local steroids to the conjunctiva 4 weeks prior to surgery increases long-term success of the filtering bleb function.

• Authors: E M Hoffmann, N Pfeiffer
• Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft (Ophthalmologe) Vol. 115 Issue 6 Pg. 521-523 (Jun 2018) ISSN: 1433-0423 [Electronic] Germany
• Vernacular Title: Trabekulektomie mit Mitomycin C : Videobeitrag.
• PMID: 29589148 (Publication Type: Journal Article, Review)

Chemical References

• Mitomycin

Topics

• Conjunctiva
• Intraocular Pressure
• Mitomycin
• Tonometry, Ocular
• Trabeculectomy
• Treatment Outcome