Connective tissue growth factor (CTGF) from basics to clinics.

Abstract

Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. Here, we describe the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. We further outline the preclinical and clinical studies concerning compounds targeting CTGF in various pathologies with the focus on heart, lung, liver, kidney and solid organ transplantation. Finally, we address the advances and pitfalls of translational fibrosis research and provide suggestions to move towards a better management of fibrosis.

• Authors: Yasaman Ramazani, Noël Knops, Mohamed A Elmonem, Tri Q Nguyen, Fanny Oliveira Arcolino, Lambert van den Heuvel, Elena Levtchenko, Dirk Kuypers, Roel Goldschmeding
• Journal: Matrix biology : journal of the International Society for Matrix Biology (Matrix Biol) Vol. 68-69 Pg. 44-66 (08 2018) ISSN: 1569-1802 [Electronic] Netherlands
• PMID: 29574063 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• CCN2 protein, human
• Connective Tissue Growth Factor

Topics

• Biomarkers (metabolism)
• Cell Adhesion
• Cell Differentiation
• Cell Proliferation
• Connective Tissue Growth Factor (chemistry, genetics, metabolism)
• Fibrosis
• Gene Expression Regulation
• Humans
• Neoplasms (metabolism)
• Translational Research, Biomedical
• Wound Healing